MODERN INSTRUMENTAL METHODS FOR QUALITATIVE AND QUANTITATIVE ANALYSIS OF LAPATINIB IN BIOLOGICAL FLUIDS AND DOSAGE FORMS (REVIEW)

Lapatinib is a small molecule, heterocyclic quinazoline derivative. The drug used for targeted therapy of patients with breast cancer, in which there overexpression the human epidermal growth factor receptors (HER/ErbB). This review devoted to studying modern instrumental methods qualitative and quantitative analysis lapatinib, can be both quality control standardization (of bulk pharmaceuticals dosage forms) pharmacokinetics studies drug. Reverse-phase high-performance liquid chromatography (RP-HPLC) mainly identify lapatinib tablets. Depending on purpose study, various detectors are (ultraviolet or diode-matrix detector), makes it possible determine not only native compound but also products its degradation. Definition presence degraded necessary forced degradation stability. When being developed, important define understand pharmacokinetics. For such studies, (HPLC) coupled mass selective detector often used. It allows determining biological fluids. However, these applicable identifying directly forms require further development validation.